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This design can now be viewed as a mixed design because it has bothwithin-subjects and between-subjects components. The PbtO2 ischemic threshold waspresent an average of 13 hours prior to herniation in 45% of patients. Generally themajor causes of the impedance can be catego-rized into either the forces related to the (1) elas-tic resistance of tissue and alveolar gas/liquidinterface and (2) frictional resistance to gas ?ow.Under static conditions when no gas is ?owing,it is the elastic resistance to gas ?ow that governsthe relationship between pressure and lung vol-ume

Generally themajor causes of the impedance can be catego-rized into either the forces related to the (1) elas-tic resistance of tissue and alveolar gas/liquidinterface and (2) frictional resistance to gas ?ow.Under static conditions when no gas is ?owing,it is the elastic resistance to gas ?ow that governsthe relationship between pressure and lung vol-ume.

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